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The uncontrolled increase of vascular permeability is the major obstacle in treatment of severe burns.
A passive, uncontrolled increase of temperature should be avoided in the modern temperature management approach.
The pathological changes during MH crisis are based on an uncontrolled increase of myoplasmic calcium, resulting in an ongoing skeletal muscular contracture and loss of cellular integrity leading to hyperkalemia and rhabdomyolysis [ 28].
One of the existing theories assumes that secretion of this factor may increase due to catabolic wasting process and uncontrolled increase of energy expenditure in adipose tissue during cachexia [ 16, 19].
Tumor-induced neurodegeneration is also associated with the development of tumor-induced cerebral edema 7, 40, the uncontrolled increase of which is a major cause of morbidity and death in gliomas due to cerebral herniation 10, 40, 41.
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Deep sedation is recommended to avoid uncontrolled increases of ICP [ 27, 28].
All these circumstances create a potentially danger situation in which cerebral structures exposed to the "dead space" of nasal cavity are not only disabled of dissipation of their normal metabolic heat, but are also subject to uncontrolled increases of temperature, due to intense illumination and surgical manipulations.
Uncontrolled increase in scope of work.
Indeed hypotony is a significant risk of glaucoma surgery, and is mostly associated with a lack of definable boundaries to the bleb, thus the bleb is seen to 'run away' (i.e. an uncontrolled increase in size of the bleb).
Because the E2 protein is a repressor of E6 and E7 expression, the loss of E2 leads to an uncontrolled increase in the levels of these oncoproteins.
Our finding provides evidence that cystatin C regulates Erk activity in PC3 cells and that loss of cystatin C might lead to an uncontrolled increase in the activity of MAPK/Erk signaling cascades, and thereby result in an increase in invasion of PC3 cells.
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