Dr. Chobanian, whose New England Journal report was titled "The Hypertension Paradox: More Uncontrolled Disease Despite Improved Therapy," noted that "in the majority of patients, two or more antihypertensive drugs are required to achieve target blood-pressure levels".
In contrast to nonneoplastic processes, the usual outcome of an unsuccessful treatment in head and neck cancer is death from uncontrolled disease.
Disturbances of oxidative burst and phagocytic activities in neutrophils of diabetic patients compared to uncontrolled disease support the importance of neutrophil functions in the treatment and follow up of diabetic patients.
Damage is in turn triggered by uncontrolled disease activity and especially by the long-standing corticosteroid use which often accompanies SLE patients over their disease course, owing both to the need of reaching disease remission and to the habit of keeping patients on a small steroid dose for an indefinite period of time.
Participating subjects were presented with a questionnaire in order to determine the knowledge they possessed on repercussions the disease might exert on their oral health, within the frame of our basic health zone, as well as risks encountered when receiving dental care in a state of uncontrolled disease.
Patients with chronic uncontrolled disease (including uveitis) for more than 3 years were excluded to avoid altered personality secondary to the disease.
Aside from incomplete understanding of immune tolerance, discrepancies arising from a continuum of 'autoimmune' reactions – ranging from normal physiological and inflammatory processes to uncontrolled disease – have destabilized the self/non-self dichotomy.
Symptoms may seem benign -- increased hunger, excessive thirst, frequent urination, weight loss, fatigue -- but undiagnosed or uncontrolled disease can take a toll on the body's nerves, eventually damaging the eyes, kidneys and lower limbs, and can raise the risk of a heart attack or stroke.
Besides, n-STZ diabetic rats in this study have an uncontrolled disease duration roughly equivalent to 6 human years, which is relatively long [1].
Experimental studies confirmed that IP-10 plays an outstanding role in uncontrolled disease development as the blockade of IP-10 by an anti-IP-10 antibody was sufficient to decrease disease severity in IL-10−/− mice.
