A reverse phenomenon occurs in attenuated insulin, IGF-1, and IGF-2 signaling (e.g., due to caloric restriction, GHR mutations, or RasGrf1−/− mice) where VSELs are protected from uncontrolled premature depletion.
However, some reports focusing on molecular analysis of the scorpion venom repertoire have proved that variations in venom composition may occur due to uncontrolled external factors, including depletion and environmental conditions [ 29, 39].
During heavy rainfall, the capacity of sewer systems and wastewater treatment plants may be surcharged producing uncontrolled wastewater discharges and a depletion of the environmental quality.
These cells seem to be protected from uncontrolled proliferation and age-related depletion by changes in imprinted genes that regulate insulin signaling [ 5].
find that their co-depletion leads to uncontrolled accumulation of contractile actin filaments, which, via the LINC complex, physically disrupt the nucleus and cause loss of cell and tissue viability.
Uncontrolled human fertility led to a depletion of the land's fertility.
What is more, marine life in rivers, lakes, seas and oceans, which feeds a great part of the world's population, is affected by uncontrolled fishing, leading to a drastic depletion of certain species.
Importantly, Nox1-induced ROS has been implicated in oncogenic signaling in Ras-transformed NIH3T3 cells, where depletion of H2O2 suppressed uncontrolled cell growth.
As the world's urban population increases, urban areas encounter new problems such as: uncontrolled use of resources, greenhouse effect, ozone depletion, …… etc.
ATP depletion can itself lead to uncontrolled calcium influx.
Our data show that βarr2 shares many of the hallmarks of proteins found at the primary cilium or involved in ciliogenesis: it is targeted to the centrosome in cycling cells and to the basal body and axoneme of PC in quiescent cells; its depletion results in accelerated and uncontrolled cell growth resulting in impaired ciliogenesis.
