A novel, minimally invasive procedure, dual-port laparoscopic abdominoperineal resection using a multichannel port, has been shown effective in patients with lower rectal cancer and patients with medically uncontrolled ulcerative colitis.
Based on this technique, we have developed a novel, minimally invasive procedure, dual-port laparoscopic abdominoperineal resection using a multichannel port, and shown its effectiveness in patients with lower rectal cancer and patients with medically uncontrolled ulcerative colitis [5, 6].
The novel, minimally invasive procedure described here, dual-port laparoscopic abdominoperineal resection using a multiple port, has been found effective in patients with lower rectal cancer [5] and in patients with medically uncontrolled ulcerative colitis [6].
An uncontrolled trial in adults with ulcerative colitis showed that administration of oral AP for seven days resulted in decreased CRP levels and improved clinical response scores [ 7].
Exclusion criteria included: evidence of brain metastases, current infection, unresolved bowel obstruction or sub-acute obstruction, uncontrolled Crohn's disease or ulcerative colitis, and a current history of chronic diarrhoea.
Ulcerative colitis (UC) is thought to originate from an uncontrolled mucosal immune response initiated by luminal microbiota.
The use of low-dose CsA to treat refractory colitis was originally proposed by us [ 14] in an uncontrolled study and later validated independently by other authors [ 7].
For instance in Crohn's disease and ulcerative colitis, coeliac disease, graft- versus-host disease and sepsis, the uncontrolled activation of the immune system results in the development of cytotoxic effector functions, and release of cytokines, which either directly damage the intestinal epithelium by inducing apoptosis or disrupt the epithelial tight junctions in between the epithelial cells.
Inflammatory bowel disease (IBD) is a chronic uncontrolled inflammation of the intestinal mucosa, which can be classified into Crohn's disease (CD) and ulcerative colitis (UC) [ 8].
