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uncontrolled brain metastases.
Patients were excluded if they had clinically uncontrolled brain metastases or peripheral neuropathy greater than WHO grade 1.
Exclusion criteria included: uncontrolled brain metastasis, pregnancy or breast-feeding, history of diabetes mellitus, diagnosis of second primary malignancy, and active or uncontrolled infection.
Key exclusion criteria included: prior chemotherapy for advanced NSCLC; uncontrolled brain metastases; symptomatic neuropathy (Grade ≥ 2); serious or uncontrolled concomitant medical disorder.
This study examines primary damage of cerebral function and tissue with uncontrolled brain reperfusion following 30 minutes of brain ischemia, and tests whether controlled brain reperfusion can attenuate the damage.
A major cause of mortality in more than 60% of patients suffering from glioblastoma is due to cerebral herniation as a consequence of massive increase in intracranial pressure caused by uncontrolled brain edema 9, 10.
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Despite maximal treatment, among the 10 patients who died in ICU, 9 had neurological complications such as uncontrolled ICHT or brain herniation and 1 patient died from massive pulmonary embolism.
Reconfiguration of the network of "cell fate" transcription factors and consequently the downstream developmental epigenetic mechanisms, could effectively silence cancer-promoting pathways that were essential for the cells to display uncontrolled proliferation and brain infiltration.
On the contrary, sustained, uncontrolled activation of brain macrophages and glial cells can lead to excess production of various pathogenic factors that contribute to neuronal injury, including the significant and dramatic upregulation of proinflammatory chemokines, cytokines and ROS.
Brain cancer, the uncontrolled growth of cells in the brain.
Liver or kidney failure, malignancy, uncontrolled hypertension, seizure, structural brain lesion, focal neurological deficit, metal implant, pregnancy.
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