Sentence examples for uncontrolled activity from inspiring English sources

Uncontrolled activity of NEK2A activates several oncogenic pathways and ABC transporters, thereby leading to CIN, cancer cell proliferation, metastasis, and enhanced drug resistance.

The monoclonal kappa light chains causes the complement activation, either directly through activity in CCP or indirectly by uncontrolled activity in CAP as described.

In fact it has been speculated that IGF-I receptor activation is necessary to repress apoptosis that would be induced by the uncontrolled activity of certain oncoproteins.

MMPs play a role in tissue remodeling, and their uncontrolled activity is associated with number of diseases, including tumor metastasis.

Although increasing inhibition can prevent uncontrolled activity, this action simply moves the network away from the point of instability rather than removing the unstable regime.

The structure of the synthesized inhibitors was designed to target human neutrophil elastase, a serine protease whose uncontrolled activity may lead to development of several pathophysiological states such as rheumatoid arthritis, cystic fibrosis or tumor growth and invasion.

Altogether, these activities result in uncontrolled plasmin activity.

First, the lack of active serpin results in uncontrolled protease activity and tissue destruction; this is seen in the case of antitrypsin deficiency.

Remarkably, the peptide killed cancer cells exhibiting uncontrolled Akt activity, while cells bearing the normal Akt activity were unaffected.

Uncontrolled E2F activity has been shown to activate an ATM-dependant growth-suppressive DDR (Powers et al, 2004; Rogoff et al, 2004).

As the encyclical notes, Paul VI first raised the issue as long ago as 1971, describing it as a "tragic consequence" of uncontrolled human activity.