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Cluster headache patients can be treated with evidence-based or guideline-recommended treatments [10, 13, 22 26], but mistreatment is often reported [19 21] and treatments that are proven as not effective, as in the case of indomethacin [27] or single high dose steroids [28], or have unconfirmed efficacy, as in the case of octreotide [29] are internationally often used.
29 Such study designs are ethically and practically justified when no alternative treatments are available in order to facilitate earlier access for patients to potential therapeutic advances, despite the increased likelihood of postmarketing safety problems and unconfirmed efficacy associated with expedited drug approvals.
Similar(58)
With one confirmed responder and three unconfirmed responders at the interim analysis, a lack of efficacy for the drug combination was concluded as per the statistical design, and the trial was closed for accrual.
Although these findings on fluids in uncontrolled haemorrhagic shock are inconclusive, the strategy of delaying fluid resuscitation must be deemed unconfirmed as well, because the only study to examine the efficacy of this approach yielded barely significant findings.
Predefined efficacy endpoints were investigator-assessed response rate (as best response, unconfirmed), PFS (time from start of first-line therapy to investigator-assessed progression or death, whichever occurred first), and OS (time from start of first bevacizumab administration to death).
But it is unconfirmed.
His claim is unconfirmed.
Rumors flew, unconfirmed.
Specs: Unconfirmed as yet.
However, this is unconfirmed.
This report remains unconfirmed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com