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We show that postnatal deletion of mouse Ate1 (its unconditional deletion is embryonic lethal) causes a rapid decrease of body weight and results in early death of ∼15% of Ate1-deficient mice.
(Unconditional deletion of Ate1 results in embryonic lethality [10].) Described and discussed in Results is a large set of defects, some of them quite striking, in juvenile and adult mice upon the postnatal inactivation of Ate1 and the resulting loss of N-terminal arginylation (Figs. 1C, D).
Although unconditional deletion of frataxin in mice causes early embryonic lethality [ 9], Cre/ loxP conditional knockout mice [ 10– 12] and GAA repeat knockin mice [ 13] unambiguously reflect important physiological and biochemical features of the human disease.
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Unconditional surrender!
"Unconditional love.
PINOCHET: Unconditional surrender!
"It was unconditional.
Another day, another deletion.
(Deletion is outlawed).
The unconditional love of millions.
He wants our unconditional surrender.
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