The sort of uncomplicated, risk-free sappiness (from "Everglow": "This particular diamond was extra-special") peddled by a band like Coldplay feels suspicious precisely because it's so effective.
In the Nordic countries, pretty much every pregnant woman has access to a skilled and trained midwife - and most uncomplicated, low risk pregnancies and births are routinely handled by midwives, from prenatal care through labor and during postpartum.
The limited evidence available (Grade D evidence) suggests that home-based care for certain subsets of women with uncomplicated high-risk pregnancy has no apparent disadvantage compared with hospital-based bed rest and monitoring in terms of impact on stillbirths and perinatal mortality.
To-date trial evidence supports the recommendation to lower systolic BP below 140 mmHg in grade I uncomplicated low cardiovascular risk hypertensive patients, based on the fact that in most trials that involved these patients (although often their "uncomplicated low-risk hypertension category" was questionable [ 4]), a reduction in cardiovascular events was associated with systolic BP <140 mmHg.
If non-attendance following referral is a risk, uncomplicated anogenital infection can be treated in GP. 35 36 However, care pathways for partner notification and test of cure should be in place, as infection may be a marker that the patient belongs to a higher risk sexual network.
To have skilled providers at the primary health center level with the confidence to attend low-risk, uncomplicated deliveries would surely contribute to the reduction of non-necessary referrals.
They found a 52% reduced risk of uncomplicated malaria in G6PD-deficient females when the deficiency was assessed using enzyme activity.
However, in females, when G6PD deficiency was defined by enzyme activity, deficiency was associated with a 52% reduced risk of uncomplicated malaria.
Thus, we repeated the association analysis, comparing the relative risk of uncomplicated malaria in females defined as both genotypically and enzymatically deficient to those females who were both genotypically wild-type and enzymatically normal.
We previously showed in this cohort that G6PD deficiency, as assessed solely by enzymatic assay, was associated with a significantly lower risk of uncomplicated malaria in females (relative risk (RR) = 0.48, 95% CI 0.31 0.75, p-value = 0.001) but not males (RR = 0.83, 95% CI 0.55 1.26, p-value = 0.39) [8].
A recent study in Papua New Guinean children 5 14 yrs of age found that despite acquiring a similar number of new blood stage infections with P. falciparum and P. vivax, children had attained very high levels of clinical immunity to P. vivax but remained at significant risk of uncomplicated P. falciparum illness [5].
