Adherence can be influenced by several factors under the control of a health-care provider including the selection of a well tolerated ART regimen with an uncomplicated dosing schedule.
The guideline was in cartoon format and had pictorial illustrations of some common clinical features of uncomplicated malaria, the correct dose and regimen of AL according to the age of the child [Fig 1].
The model projects the number of doses needed, uncomplicated and severe cases averted, deaths and disability-adjusted life years (DALYs) averted, and cost to avert each.
The first-choice treatment for uncomplicated syphilis remains a single dose of intramuscular benzathine penicillin G. Doxycycline and tetracycline are alternative choices for those allergic to penicillin; however, due to the risk of birth defects these are not recommended for pregnant women.
As the pyrexial episodes were relatively uncomplicated, we would recommend this dose for evaluation in phase II studies.
The dosage may not be sufficient for the complicated lower UTI, but may exceed the required dose for acute uncomplicated cystitis.
In recent years, numerous clinical pharmacokinetic and therapeutic drug monitoring programs have been launched to assess the adequacy of drug doses and to model dose response in uncomplicated and severe malaria (18 – 20).
The era of single dose monotherapy for uncomplicated STIs such as M. genitalium and N. gonorrhoeae, while convenient for patients and physicians, has been associated with escalating resistance and treatment failure and is now drawing to a close.
As it has been the case for N. gonorrhoeae, the rapid development of resistance in M. genitalium highlights the fact that the era of single dose therapy for uncomplicated STIs is long past.
A meta-analysis of chlamydia treatment options showed a slightly better cure rate of 3%% with doxycycline compared with single dose azithromycin for uncomplicated chlamydia infection, but a 7%% better cure rate with doxycycline for clinical urethritis [ 51].
Background: The pharmacokinetic profile of azithromycin supports its use as single-dose therapy for uncomplicated acute otitis media (AOM) in children.
