In our series, the percentage of patients having this uncommon variation was 0.057 %, in accordance with the published studies [16, 17].
In our series the percentage of patients having this uncommon variation was 0.057 %, lower than the reported angiographic percentage in other published CTA studies [3, 11].
Notably, while intra-laboratory variation of HI titers of up to 2-fold in replicate assays is not uncommon, variation of more than 2-fold is rare [ 20].
The 1000 Genomes Project (3) has helped enhance our understanding of low-frequency and rare variants by providing a catalogue of common and uncommon variation through WGS and exon sequencing across several global populations.
Some uncommon anatomic variations would be encountered with the increasing number of patients with chronic paranasal sinusitis who have undergone functional endoscopic sinus surgery.
The uncommon genomic variations in the two closely related BL196 and CR0044 strains suggests that S. Typhi is more diverse than previously thought.
Given the growing recognition of the genetic and clinical variation seen in this disease, the development of comprehensive bioinformatics-driven tools to both analyze response in uncommon mutation subtypes and inform clinical decision making will be increasingly important.
Thus, TLR genes are substantially conserved, but episodic positive as well as transient balancing selection are not uncommon and variation segregating in populations may be of adaptive significance (Tschirren et al. 2012, 2013).
Therefore, in addition to the lack of common variation downstream of intron 6 in humans, SLC2A4 has an uncommon pattern of variation in Africans, characterized by a high number of segregating sites and singletons but low nucleotide diversity.
However, inter- and intraobserver variability is a problem inherent to morphologic tumour classification and grading (Sloane et al, 1998); moreover, heterogeneity within DCIS lesions is not uncommon, resulting in variation in grade (Ma et al, 2003).
