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In our series, the percentage of patients having this uncommon variation was 0.057 %, in accordance with the published studies [16, 17].
In our series the percentage of patients having this uncommon variation was 0.057 %, lower than the reported angiographic percentage in other published CTA studies [3, 11].
Notably, while intra-laboratory variation of HI titers of up to 2-fold in replicate assays is not uncommon, variation of more than 2-fold is rare [ 20].
The 1000 Genomes Project (3) has helped enhance our understanding of low-frequency and rare variants by providing a catalogue of common and uncommon variation through WGS and exon sequencing across several global populations.
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It is possible however, that the sample number of pigs in the current study was not sufficiently high to observe uncommon variations.
Thus, TLR genes are substantially conserved, but episodic positive as well as transient balancing selection are not uncommon and variation segregating in populations may be of adaptive significance (Tschirren et al. 2012, 2013).
Given the growing recognition of the genetic and clinical variation seen in this disease, the development of comprehensive bioinformatics-driven tools to both analyze response in uncommon mutation subtypes and inform clinical decision making will be increasingly important.
Some uncommon anatomic variations would be encountered with the increasing number of patients with chronic paranasal sinusitis who have undergone functional endoscopic sinus surgery.
The uncommon genomic variations in the two closely related BL196 and CR0044 strains suggests that S. Typhi is more diverse than previously thought.
However, inter- and intraobserver variability is a problem inherent to morphologic tumour classification and grading (Sloane et al, 1998); moreover, heterogeneity within DCIS lesions is not uncommon, resulting in variation in grade (Ma et al, 2003).
Mammalian genes of over 200 kb and twofold differences in elongation rates between genes are not uncommon, leading to variation in response time of mRNA production of an hour or more.
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