In contrast, Winkelmuller and Winkelmuller [ 6] found a mean dose of 5.6 mg/day of morphine at an average follow up of 3.4 years and drug tolerance was uncommon.
Furthermore, pharmacodynamic tolerance is not an uncommon clinical occurrence.
The results on freeze and thawing, UV exposure and osmotic stress tolerance here reported highlight an uncommon ability of surviving under these external pressures.
Comparable to ipilimumab, tremelimumab also leads to tumour regression, and also to uncommon toxicities, including dermatitis, colitis, hepatitis and hypophysitis, indicating that immunological tolerance was broken in some patients treated with CTLA4 blockade.
But stress ulceration has become distinctly uncommon [ 10], and so other metrics have been sought, including tolerance of enteral feeds, ileus and nasogastric drainage, intestinal ischemia, acalculous cholecystitis, and diarrhea [ 11].
Because the development of tolerance and dependence during long-term tramadol treatment is uncommon and its abuse liability appears to be low, it is an alternative to strong opioids in neuropathic pain.
The production dimensions of a contemporary prestressed high performance concrete sleeper are within low tolerance values on the scale of a millimeter that is uncommon for ordinary structural concrete elements.
Carlini [23] changed common leucine codons to uncommon counterparts in the alcohol dehydrogenase gene of Drosophila and found decreasing tolerance to alcohol with increasing numbers of uncommon codons.
Muslim leaders must continue to emphasize the guiding principles of their faith - justice, tolerance, charity, compassion and equality - and speak out against honor killings, which are not uncommon among their communities in Europe.
(3) Uncommon forms of encephalopathic epilepsy: a proposed design includes randomization to sequential monotherapy with prescribed titration/dose defined by seizure control or tolerance.
