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Circumventing spurious positive events and recognizing uncommon cells subsets delineate the challenge in all these applications.
Hamburger and Salmon [ 8] first proposed the CSC theory, which posits that cancer originates from uncommon cells that demonstrate pluripotency and selfrenewal [ 9].
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Injectable organic gadolinium compounds are also used as a contrast agent for MRI, which allows doctors to better locate uncommon cell growths and tumors.
Another DC subset that can be identified in peripheral blood, pDCs represent an uncommon cell type that morphologically resembles plasma cells [ 10].
In addition to the healing capacity, the MRL/MpJ mouse has been found to display a number of distinctive characteristics such as increased size, autoimmunity, the existence of mitochondrial heteroplasmy [ 21], natural resistance to high fat diet-induced hyperglycaemia [ 22], and uncommon cell cycle profile [ 23].
Nuclear fragmentation was uncommon in cells treated with SAHA, PLX4720, or SAHA plus PLX4720.
It is also not uncommon that cells isogenic for a particular oncogene or tumor suppressor gene differ with respect to variables such as proliferation rate and cell-cycle distribution, which can potentially confound synthetic lethal screens.
While historically uncommon, merkel cell carcinoma (MCC) incidence has risen steadily over recent years [ 1, 2].
There is increased evidence of association between CLL and skin cancers, including the uncommon Merkel cell carcinoma (MCC).
Waldenström macroglobulinemia (WM) is an uncommon B-cell lymphoproliferative disorder characterized by bone marrow lymphoplasmacytic infiltration and by the presence of a monoclonal IgM immunoglobulin in the serum [ 1].
Waldenström's macroglobulinemia (WM alternatively designated as lymphoplasmacytic lymphoma is an uncommon B-cell lymphoproliferative disorder (LPD) characterized primarily by a lymphoplasmacytic infiltration of the bone marrow and by an immunoglobulin M monoclonal gammapathy.
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