Although the clinical implications of these findings remained unclear, the safety issue related to compound A formation led to intense debates for many years before the issue was resolved.
160– 162 Because rheumatoid arthritis patients are usually on concomitant systemic immunosuppressants while psoriasis patients are typically treated with monotherapy, it is unclear if safety data from rheumatoid arthritis studies can be generalized to psoriasis.
As few or none prescriptive guidelines for fire risk assessment of residential high-rise buildings exist, it has been unclear which fire safety design features constitute an acceptable (adequate) safety level.
The General Accounting Office report concludes that tighter standards would reduce gasoline consumption and emissions of gases that contribute to global warming, but would have an unclear effect on safety.
Therefore, it is unclear, whether available safety formats lead to the intended reliability when they are applied to structures that fail due to shear loading.
In RCTs, the prevalence of severe infection is less than 10% [ 3- 16], but it is unclear whether the safety data obtained in these trials can be extrapolated to clinical practice.
It is currently unclear from efficacy, safety, tolerability or health economic perspectives whether mild or maximal ovarian stimulation (with cryopreservation of supernumerary embryos) is most beneficial (Fauser et al., 2005).
15 16 Such findings highlight the need for classification criteria with improved performance characteristics, with higher specificity likely to be favoured in order to ensure that individuals enrolled into trials for treatments with unclear efficacy and safety truly have gout.
