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Two other BRD-containing proteins, SMARCA2 (BRM) and BRD1, have been identified in genome-wide association studies as susceptibility genes for schizophrenia and bipolar disorder in several independent studies, but the molecular mechanisms are still unclear (Refs 162, 163).
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The neural mechanisms by which we categorize objects remain largely unclear (for overviews, see refs. [6], [7]).
3 7 8 While the CPG recommendations for the management of patients with HF-REF are unclear or ambiguous, or may appear counterintuitive, we conclude that GPs appear not to follow evidence-based CPG recommendations in their decisions on prescribing statins and β-blockers for patients with HF-REF.
The optimal dose remains unclear and the drug is administered ranging from 2500 IU m−2 (refs. 2, 4) (weekly) to 1000 IU m−2(ref. 1) (fortnightly).
Attempts have been made to develop animal models of sequestration (Refs 210, 211); however, their relevance to human disease mechanisms is unclear and unproven.
Accumulation of platelets has been reported in the brains of children dying from cerebral malaria (Ref. 139); however, the precise role of platelets in malaria pathology remains unclear.
EMT plays a key role in morphogenic changes during embryonic development and in tumor metastasis (see ref. [14] for a recent review), however its role in cell dedifferentiation remains unclear.
The mechanism underlying the tumour-suppressive activity of α7β1 remains unclear, but may involve upregulation of inhibitors of cyclin-dependent kinases and Rac family small GTPases (Ref. 52).
The refs despise us.
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