Because the goal of closure is relevant to its timing, nature, and duration, unclear rationales for closure can challenge its effectiveness.
Therefore PLANS or any self-management resource is likely to struggle for relevance where there is an unclear health rationale for action.
However, the unclear clinical rationale for the heterogeneity in the evidence base suggests that, despite the need for a further RCT, designing this study will be complex when uncertainties exist at this level.
Resistance to the PLANS intervention ranged from an unclear health rationale for doing so, the double disruption of introducing a new intervention together with the unexpected knowledge that they were suffering from CKD, or the perception that their social life was under scrutiny.
With respect to bare materialism taken on its own, it is also unclear what its rationale is for asserting materialism, even one of this minimalist variety, which focuses on substances (the person or perhaps the body) rather than events undergone by substances.
While the molecular mechanism for this dramatic change is unclear, one possible rationale is a lower energy of desolvation for the alanine mutants, compared to that of the native protein.
But the "Family Guy" staff remains unclear on Fox's rationale.
His full rationale is unclear at this time, but I suspect we need look no further than the treatment meted out to other defence and security whistle-blowers: Manning, Snowden, Vananu, Kiriakou and so on.
It was around this time that Laurie, who was originally his manager, then girlfriend, then wife (it's unclear to them what rationale drove the transition), persuaded him to abandon the vagaries of acting and focus on the vagaries of writing.
