Although the mechanism(s) for these changes remain unclear, possibilities include an increased avidity of the viral envelope glycoprotein for CXCR4 and/or the increased exposure of the chemokine receptor binding site.
Within extracellular microenvironments, nevertheless, how SFRP2 augments WNT16 activities remains unclear; one possibility is that mutual binding of two secreted proteins may increase their individual stability, particularly in a context of protease-enriched TME milieu including multiple MMPs that are co-released by the treatment-damaged stroma (Figure 1a).
Although the origin of fluid is unclear, one possibility is that there is a little fluid in a closed system beneath the Tanzawa Mountains that is undetectable by structural observations.
Though the reason is unclear, one possibility would be that the estimated stress drop of the earthquake was the least robust among the analyzed earthquakes because the earthquake had the largest standard deviation of estimated stress drop, which was calculated from individual corner frequencies of waveforms observed by the individual components of stations.
Whilst the mechanism of repair is unclear, one possibility is that repair may occur during the reverse transcription process.
Although the molecular nature of the mutation is unclear, one possibility for this observation is that the gene product of Caf1p55 long retains some CAF1p55 function that is able to resist Psc overexpression.
The reason for this is still unclear; one possibility is that the use of bevacizumab could decrease interstitial pressure, improve tissue oxygenation, and increase delivery of irinotecan to the tumor [ 37, 38].
Although the explanation is unclear, one possibility is that women with severe knee OA may have less physical (walking) activity, which could lead to lower bone mass than women of comparable age.
Why S. rosetta GKPID can bind the Drosophila Pins linker but not its own is unclear; one possibility is that the surface of GKPID that fortuitously binds Pins is conserved in S. rosetta because it binds another structurally similar ligand, possibly an ancient one.
Possible roles of ROS in resistance to insects are unclear, and possibilities include direct toxicity to the insect gut, or acting as a signalling molecule that results in the upregulation of defence genes [52].
While the exact mechanism for this renewal remains unclear, two possibilities have been proposed: differentiated myocyte replication and progenitor/immature cell differentiation.
