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Although the relationship of economic indicators with health is unclear, lower income has been associated with morbidity [ 15].
Although the expression of splice variant 6 at the protein level in monocytes from RA patients was unclear, lower expression of RasGRP4 and/or that of functionally abnormal RasGRP4 isoform might affect the development of monocytes into macrophages or osteoclasts, resulting in altered function of these cells in RA patients.
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More importantly, it provides potential therapeutic entry points for HD: while the mechanism of mHtt toxicity is unclear, lowering its level should suppress its downstream toxicity and treat the disease (Yu et al., 2014).
However, it is still unclear whether lower skeletal muscle mass increases the risk for bone fracture.
Supraphysiological concentrations of exogenous growth factors are typically required to obtain bone regeneration, and it is unclear why lower levels are not effective.
It is unclear why lower courts should be given a power to narrow rulings of higher courts in this particularly circumscribed manner.
What can change the situation is unclear, as lower oil prices sap the Iraqi economy, the U.S. limits its involvement on the ground and the Iraqi people as a whole continue to suffer.
It is unclear whether lower blood lead levels are associated with more severe behavioral problems such as CD in children.
At present, it is unclear whether lower D2/3R availability is a cause or an effect of obesity.
Although this rMIF concentration is well within the range of MIF concentrations measured and known in pathophysiologic conditions to promote inflammation and pro-tumourigenic behaviour, it is currently mechanistically unclear why lower concentrations of rMIF (10 50 ng/ml) sufficed to lead to an enhancement of breast cancer cell proliferation and invasion.
It is still unclear whether lower LPA levels or impaired glycolytic metabolism occurs first upon INPP1 knockdown, but we provide compelling evidence that LPA and glycolytic metabolism are intricately linked and that INPP1 modulates this coupled metabolic and signaling programming in cancer cells.
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