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With the exception of 36 genes that have been suggested to exert dual effects or unclear effects on cell growth or cell death (D), 85 genes (N+P) were to positively or negatively affect cell growth or cell death (Table 2 and Table S4).
Among them, 86 genes are down regulated and 67 genes are up regulated; 109 genes (N+P) are reported positively or negatively regulating cell growth or death and the other 44 (D) may have dual effects or unclear effects on cell activities (Table 1 and Table S2).
In fact, low-dose corticosteroids and MTX have unclear effects on the RA cytokine network.
The investment of resources in interventions with unclear effects must, in the light of increasingly scarce resources, be critically questioned.
Additionally, the practice of continuous deep sedation until death often occurs, which is much debated because of its unclear effects on life shortening.
In the absence of rigorous evidence to guide clinical practice, many strategies employed to treat common illnesses in the general public have been adapted to treat the ESRD population, with unclear effects on patients' clinical outcomes [ 11- 18].
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(Greece received $50 billion, an enormous amount in per capita terms, also to unclear effect).
The General Accounting Office report concludes that tighter standards would reduce gasoline consumption and emissions of gases that contribute to global warming, but would have an unclear effect on safety.
But even if that's true, it's not really very surprising plenty of potential new drugs may have a marginal or unclear effect.
These bacterial associates with unclear effect include: (1) two of the fungal sequences having plant pathogens (resp. Didymella and Rhizoctonia) among their closest relatives.
A concern expressed about the use of metformin in cancer patients is its unclear effect on glucose levels in non-diabetic patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com