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In some cases, we have seen evidence of overlapping or unclear allocation of responsibilities.
Excluding trials with unclear allocation concealment or unclear double-blinding.
Inadequate or unclear allocation concealment exaggerated odds ratios by 41%and30%0%, respectively.
The evidence base for the benefit or lack of benefit of corticosteroids in dengue is limited; previous studies have been small, with methodological flaws, less stringent randomisation and unclear allocation concealment, and were performed a long time ago.
Of the 37 African trials reporting inadequate or unclear allocation concealment, 27% (10/37) were led by African PI.
For instance, numerous meta-epidemiological studies have demonstrated that RCTs with inadequate or unclear allocation concealment can overestimate treatment effects by 18% on average [2].
Similar(16)
*High because of unclear randomisation, allocation concealment, and blinding.
In the other four studies, risk of bias was unclear because allocation information was not provided [ 28- 31].
Nevertheless, it is unclear if allocation of antimicrobial proteins to eggs is particularly costly for mothers in terms of energy and nutrients (Saino et al. 2002; Shawkey et al. 2008).
In this study we showed that insufficient knowledge of care professionals, unclear task allocation, and a lack of collaboration within, and between, inpatient and outpatient settings are important barriers from the perspective of the health care professionals.
We judged an unclear risk for allocation concealment because masking of allocation was not described in full detail.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com