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As expected, because of the relatively unchanged specificity, reevaluation of the patients included in our study according to the new criteria did not change the clinical diagnosis in any patient.
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When genotyping assay sensitivity is held unchanged and specificity is decreased from 0.95, to 0.90, 0.85, 0.80, composite prevalence estimates increase and the estimated-to-true ratios become much larger (Table 1b).
The cut-off applied to the CI + PI index can also be selected to leave specificity unchanged when using EIS as an adjunct to colposcopy.
Surface levels of the T cell lineage marker Thy1.2 remained unchanged, confirming the specificity of the TCR down-modulation (Fig 1E).
Because of the ability to change the cut-off applied to the EIS measurement it is also possible to select a value that leaves specificity unchanged when using EIS as an adjunct.
The sensitivity of the LAM-specific ALS assay in AFB+ patients decreased from 92% to 87% in AFB− patients, the specificity remained unchanged at 87%.
Specificity remains unchanged.
Only the constant region of the antibody heavy chain changes during class switching; the variable regions, and therefore antigen specificity, remain unchanged.
Sensitivity increased and the amount of uncertain classifications decreased, while specificity was unchanged.
Sensitivity increased significantly, while specificity was unchanged, and the number of uncertain classifications decreased significantly.
For example, in biopsy samples, the sensitivity is improved from 84.7%to88.2%2% while the specificity is unchanged (91.9%).
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