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The model also characterizes the uncertainty in the ordering and provides a natural patient staging system.
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The positional variance diagrams generated directly from the EBM (Fig. 1A D) underestimate the uncertainty in the event ordering, as they do not account for uncertainty in the biomarker distribution models.
The optical micro-probe is designed to perform dimensional measurements with a target uncertainty in the order of few nanometers.
The calibration results showed an improvement in the calibration range between 0.600 g/ml and 1.000 g/ml with uncertainty in the order of 0.0002 g/ml for hydrometers with scale graduations of 0.0005 g/ml.
We have found that, due to the small-scale mechanical uncertainty (in the order of the voxel size), a recalibration is necessary for each geometric setup after repositioning of the system's components; the resolution losses due to the lack of recalibration are worse for the HR setup (voxel size = 18.4 μm).
We also considered a uniform prior on the logarithmic scale to allow for uncertainty in the order of magnitude, and a similar 95% CI is obtained (i.e., [0.060, 0.70] mutations per haploid genome).
This is especially challenging for SMLM-based co-localization, since the images are rendered from single fluorophore locations that are usually determined with an uncertainty in the order of 15 50 nm (Mortensen et al. 2010; Thompson et al. 2002).
Normal dose uncertainties in the order of 20% might easily make the difference between seeing a dose-effect or missing it altogether.
Even low levels of error result in large losses of information about breakage probabilities, markedly increase the uncertainty in the marker ordering, and inflate estimates of inter-marker distances and total map length [ 17].
Comparison with available growth data indicates that this uncertainty is in the order of 20%% or less.
The total uncertainties of the tritium production prediction including the data uncertainties, the statistical uncertainties of the Monte Carlo calculation and the experimental uncertainties are in the order of 8to10%0% (2σ).
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