Response initiation was studied using a light dark discrimination reaction time task that required a correct response within 2.5 s of a spatially and temporally uncertain stimulus onset.
c) Focal neurological deficit (mode of onset uncertain) lasting at least 24 h or leading to death, plus evidence from neuroimaging showing infarction, or postmortem examination showing infarction.
c) Focal neurologic deficit (mode of onset uncertain) lasting at least 24 h or leading to death, plus evidence from neuroimaging or postmortem examination showing primary intracerebral and/or cerebellar hemorrhage.
Extending the time window for inclusion and including patients with uncertain time of onset would result in more patients being eligible, but would defeat the purpose of an evaluation of very early treatment.
At last, it still remains uncertain whether new-onset AF in patients with sepsis is merely a marker for severity of disease, or whether it truly impacts outcome.
The Little Ice Age has been abundantly depicted in contemporary accounts of advancing mountain glaciers that destroyed villages and paintings of ice-skating on frozen Dutch canals or on London's River Thames, but the date of its actual onset was uncertain.
The latency period between exposure and disease onset remains uncertain.
In five of the patients presented here, where rapid onset and uncertain or absent family history complicated the clinical picture (VI.15, VI.9, VII.7, 4.VII.1 and 6.VIII.1), the diagnosis of sCJD was considered; indeed, one patient (VI.9) met World Health Organisation's diagnostic criteria for probable and the others possible sCJD.
Determination of the actual time of onset can be uncertain; it is even possible that PLCH diagnosed at an adult age may have had its onset in childhood (Fig. 1) [13].
Thus, it is uncertain whether earlier or later onset of administration may represent prophylaxis or treatment in a clinical setting.
