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Castoe et al. [10] showed that sea urchins (Strongylocentrotus purpuratus and Lytechinus variegatus), birds (Gallus gallus), and fish (Danio rerio and Tetraodon nigroviridis) harbour PKS-like proteins with uncertain functionality, which are closely related to PKS members of Dictyostelium.
However, our findings indicate that an approach which combines tissue-engineered urothelium with host smooth muscle may provide a more robust approach than one dependent upon the uncertain functionality of tissue-engineered smooth muscle.
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Scrubbers, LNG, and methanol functionality are uncertain and best suited for newer vessels or new builds.
Of the two variants addressed here, rs237900 is intronic, and its functionality is uncertain.
The genome also contains a gene with homology to the chloroplast trnM gene (which recognizes internal AUG codons), but it has experienced a large expansion in its anticodon loop, making its functionality (and its anticodon) uncertain (Additional File 2).
The functionality of this transcript is uncertain and whether it translates into increased cellular CYP2D6 protein concentration in AKI remains unknown.
At more than 1 kb long, the functionality of these repeats remains uncertain.
The condensation domain appears to be catalytically competent, whereas the functionality of the A-domain is uncertain.
Ideally polymorphisms such as rs25531 and VNTR STin2 should be included as these have also been reported to affect gene expression (Hranilovic et al., 2004), although the functionality of some of these variants remains uncertain (Parsey et al., 2006).
In engineering design, the concept of robustness is used to mitigate loss of functionality or performance due to reliance on information that is uncertain or difficult to model or compute.
The absolute stereochemistry of the cis-cyclopropane remains uncertain, although if a common intermediate is involved in producing methoxy-, hydroxy-, keto- and cyclopropane functionalities, it will be as shown in A– C (see e.g., Koza et al., 2009a).
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