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In addition, previously we reported co-detection of human bocavirus and coronaviruses with HRV during the second study year [32], [33] but did not include them in this analysis due to their uncertain association with hospitalized illness.
Curated RET oncogene mutations have been recently reported by Margraf et al. [23] The disease classification of RET gene variants has been curated as benign (6%), pathogenic (52%) and VUS (42%), meaning unknown or uncertain association with disease or phenotype outcome.
Uncertain association of putative regulatory elements and genes aside, gene annotation databases can be useful to characterize non-coding elements.
As there is an uncertain association between observed variables and missing BHR data in these participants, it was not possible to perform a robust imputation.
Furthermore, the uncertain association of Sii with human diseases necessitates further elucidation of presumptive Sii-specific virulence factors or the absence thereof in Sii.
12 Other reasons for under-reporting of an ADR in other studies were diagnosed as uncertain association, too trivial to report, too well known to report, yellow card unavailability, lack of time and not knowing how to report.
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The acceptance of even weak and uncertain associations with severe events is largely influenced by the incidence of the diseases targeted by the vaccines, which modifies the perception of the expected benefits.
Although potential mechanisms are uncertain, associations with first-trimester measures are consistent with hypotheses involving epigenetic changes, because such effects have been observed to be more frequent for periconceptional than for later exposures (Lee et al. 2009; Tobi et al. 2009).
It is uncertain why associations with systolic and diastolic blood pressure differ.
However, it is uncertain whether this association applies to other immune-mediated diseases.
It is uncertain whether the association between anemia and mortality is causal or whether anemia is rather a marker of progressive HIV disease.
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