While the molecular mechanism of how this is achieved is uncertain, altered protein protein interactions (Wu et al., 2000; Vazquez et al., 2001; Sumitomo et al., 2004; Takahashi et al., 2006; van Diepen et al., 2009; Huang et al., 2012) as well as conformational changes (Odriozola et al., 2007; Rahdar et al., 2009) in PTEN have been suggested to be induced by phosphorylation.
It is also uncertain whether altered synovial HDAC activity influences therapeutic strategies targeting the balance of synovial protein acetylation, as HDAC inhibitors are uniformly effective in animal models of RA [ 5] and demonstrate anti-inflammatory properties in RA FLSs [ 6], synovial macrophages, and synovial biopsy explants [ 7].
However, it remains uncertain if altering the solubilizing agent leads to differences in the conformational states of MPs in the gas phase and whether any general "rules" of which particular solubilizing agent is optimal for different MPs, or if each MP will behave differently, remain to be resolved.
Mechanisms underlying sepsis-induced acute kidney injury remain uncertain with inflammation and altered haemodynamics being implicated.
We suggest that the ACT framework is a practical tool for initiating adaptation planning, and for generating and communicating specific management interventions given an increasingly altered, yet uncertain, climate.
Because of the cultural noise present on these measurements, the real value of the skew at those sites and frequencies is uncertain, as it could be altered by the low quality of the data.
Until the line drawers get to work, in the spring, it is uncertain how the 32nd might be altered.
This variability can be decreased by history matching where uncertain parameters of the reservoir are altered to minimize the mismatch between history and simulated data.
At this stage, however, the primary mechanisms linking Dp71 loss to altered synaptic function remain uncertain.
The pathophysiology of altered HRV still remains uncertain, and was not the focus of this study.
With the Smell's future uncertain, L.A.'s music scene could be altered.
