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However, in hybridization experiments involving low copy number targets and longer oligos, creating extremely short target fragments may reduce or eliminate the signal on the chip, because the target can not be sheared specifically to present an unbroken hybridization site for the probe, and so some fragments will be created that match the probe only partially.
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The cycle remains unbroken.
His record remains unbroken.
3. Unbroken, by Laura Hillenbrand.
Leave my loneliness unbroken!
The bottle rolled along, unbroken.
Hybridization of national styles is nothing new.
But his sunny resolve was unbroken.
That bond, though strained, is unbroken.
The connection has been unbroken ever since.
The glass on the case is unbroken.
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