DOI: http://dx.doi.org/10.7554/eLife.06541.011 Recovery that is presumably due to the bound mobile pool is seen in fibres with no detectable or very low levels of cytoplasmic unbound huDysGFP (Table 2).
For the last and highest infusion dose (150 µg), a mean of only 0.95% of the i.p. administered catumaxomab was detected in the periphery as unbound antibody (Table 1).
Analysis of the content of methoxyl groups in the fractions showed that both Diaion-bound fractions CSP-AB and CSP-NB had a high degree of methyl esterification of the uronic acid residues when compared to the Diaion-unbound fractions (Table 2).
The DTG concentrations in CSF were similar to unbound plasma concentrations (Table 2).
Notably, a motif for STAT3 ranks first in terms of differential local enrichment in bound vs. unbound promoter regions (Table 5), compared with a best rank of 125 in terms of local motif enrichment in bound promoter regions.
For PMCA studies, we used a PrP to solids ratio one-half that used in the adsorption studies presented above to ensure no unbound PrPSc was present (Table S1).
Pharmacokinetic parameters for total and unbound darunavir are provided in Table 1.
We denote the ratio of the probability of promoter bound by RNAP to unbound by RNAP as q p (Table 2).
"Prometheus Unbound," left lying casually on an end table, is opened to a page that reads, in part, "I am as a drop of dew that dies".
The performance of FlexPepDock ab-initio is summarized in Table 1 (bound docking), Table 2 (unbound docking) and Fig. 2, and specific examples are presented in Fig. 3.
