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Renal denervation has demonstrated a significant reduction in blood pressure in unblinded studies of hypertensive patients.
Many different replacement strategies for treating medication withdrawal symptoms in MOH have been proposed and found to be effective, almost exclusively in uncontrolled, unblinded studies that employed a variety of outcome measures [12, 19].
However, a number of difficulties were encountered in assessing hand hygiene studies: the problem of attributing efficacy to an alcohol-based product when used in a multi-component intervention; the variability inherent in the design of such studies; and how to use data from uncontrolled, unblinded studies in the assessment.
Several previous unblinded studies have reported dramatic effects of misoprostol when used to treat postpartum haemorrhage.
In their sensitivity analysis, excluding studies both quasi-randomised and unblinded studies, statistical significance was lost.
The calculated ICC approached values seen in prior unblinded studies if one-third to one-half of all cases of inter-rater agreement were excluded (Supplementary Fig. S1).
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Current standards for high quality evidence require that a double-blind placebo-controlled study be performed; if it is an observational study or unblinded study, all hidden variables are to be taken into consideration.
Design: Prospective, unblinded study.
We conducted a single-center, prospective, unblinded study.
Finally, this was an unblinded study, which may also have influenced the outcomes.
"These are just a few patients in a completely unblinded study; you would certainly expect some placebo effect," he says.
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