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Choices in experimental design should ensure high quality of the results in terms of precise and unbiased toxicity quantification and of statistical decisions with controlled error rates.
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Toxicity: many TOXIC.
Identifying critical proteases involved in Htt proteolysis and toxicity using an unbiased approach has not been reported.
Furthermore, an unbiased assessment of the contaminant toxicity also requires that account is taken of the imprecision, both of the contaminant exposure and of the proxy variable that reflects the confounding factor.
We conducted evaluation experiments on 17 maximum unbiased validation (MUV) data sets, an Ames toxicity data set (Kazius), and a chromosome aberration (CA) data set.
The Human Toxome Project proposes to apply unbiased multiomic tools to map pathways of toxicity (PoTs) in human cells (Hartung and McBride 2011).
We performed two unbiased screens in Saccharomyces cerevisiae and identified potent modifiers of DPR toxicity, including karyopherins and effectors of Ran-mediated nucleocytoplasmic transport, providing insight into potential disease mechanisms and therapeutic targets.
The molecular identification of genetic factors that influence developmental ethanol toxicity has been hindered largely by the difficulty of performing unbiased, forward genetic screens in vertebrate systems, and it is here that our model is most useful.
With pharmaceutical compounds as baits, drug targets and toxicity-relevant off-targets can be discovered in an unbiased proteomic screen.
We evaluated our approach on a toxicity data set, a chromosome aberration data set, and the maximum unbiased validation data sets.
In this case, machine learning and data mining techniques are applied to large toxicity data sets to identify structural alerts in an automatic and unbiased fashion.
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