Sentence examples for unbiased targeting from inspiring English sources

Although point mutation was insufficient to remove the 5′-T constraint, directed evolution from the randomized library yielded repeat-1 mutants with unbiased targeting sites for 5′-bases.

The CRLB provides a bound on the performance of any unbiased target localisation algorithm.

1– 3 Although the identification of functional ligand receptors within the tumor vasculature is challenging, we recently demonstrated that screening peptide libraries directly in humans enables unbiased target identification.

We then used FET to compare N for a given domain with the sum of N for all the other domains of the protein, while using S in the domain and sum of S in other domains as the background, with the null hypothesis that every domain in the protein is an unbiased target of non-synonymous changes.

To ascertain the unbiased target canine population and to estimate the feline population living in the Vicenza and Venice provinces, a telephone survey aimed at private households calculating the number of dogs and cats according to the number of people in the catchment area was made [ 10, 11].

TGE has been used to discover mutations in sets of genes associated with specific diseases [ 3- 5] or, in an unbiased way, by targeting the whole exome [ 2].

An unbiased screen for miRNAs targeting the 3′-UTR of NOXA led to the identification of miR-200c as a potent repressor of NOXA expression.

Here, we performed an unbiased siRNA library screen targeting the DUBs encoded by the human genome to uncover new regulators of TCR-mediated NF-κB activation.

We performed an unbiased siRNA library screen targeting the 46 E3 ubiquitin ligases bearing transmembrane domains to uncover new modulators of NF-κB activation, using tumor necrosis factor α (TNF-α) receptor (TNFR) stimulation as a model.

Sex-biased autosomal genes tended to be expressed at lower levels and in fewer tissues than unbiased gene targets, and autosomal somatic sex-biased genes had more expression noise than similar unbiased genes.

17 For each hemisphere, the mean AC PC midthickness surfaces for both groups (term control and preterm) were averaged to generate an unbiased surface target whose size is midway between the mean dimensions of the 2 groups.