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The question we wanted to address was whether (and which) ensemble methods could improve upon these baseline results in an unbiased setting.
To assess the impact of using different costs on gene tree inference, we ran TreeFix-DTL on the 50-taxon datasets from the basic simulation setup with all three event costs set to 1 (the simplest and most unbiased setting of event costs possible) and observed that performance was only slightly affected by using these alternative event costs (Supplementary Fig. S3).
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Thus, it reveals whether it is possible to trust the data, because high values of alpha (above.70) entail an unbiased set of items and sample (Cohen and Swerdlik, 2009).
The immunocomplex was incubated with an unbiased set of totally degenerate 30 bp sequence flanked by PCR priming sequences.
When an unbiased set of 15 lectins was analyzed for binding to six B-cell lines, 12 of the lectins showed significant staining.
This is in contrast to the 1176 array, which used an unbiased set of amino-acid motifs that could be phosphorylated.
By using chromatin immunoprecipitation followed either by hybridization to tiled genomic microarrays (ChIP-chip) or high-throughput sequencing (ChIP-Seq) it is possible to identify a large, unbiased set of transcription factor binding sites, suggesting candidate target genes [6], [7].
The approximately uniform distribution obtained confirms ours to be a relatively unbiased set of inhibitors.
The 1000G project provides the most unbiased set of human SNPs available to date.
Unbiased TATA Boxes, Related to Figure 5 TATA boxes from the unbiased set drawn from transcription start databases.
The larger dataset of 1619 proteins was divided into two subsets, namely the biased and the unbiased set.
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