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Consequently, together with unbiased sensitivity and specificity estimates, PPV and NPV estimates are unbiased too.
To obtain a recognition discrimination index, d′ was calculated an unbiased sensitivity measure commonly applied in recognition memory research.
Patients where all analytes were normal were not included, meaning that while True and False-Positive rates are unbiased, sensitivity and specificity may be overestimated and underestimated, respectively.
The quantitative nature and the unbiased sensitivity of the method will be useful for identifying the fates of various proteolytic products, which will complement other biochemical and cell biological studies of proteolysis [ 46].
In each run, a range of standards was included to control for unbiased sensitivity of the detection: 0% (unmethylated: EpiTect Control DNA; QIAGEN), 1% and 10% (fully methylated template in an unmethylated background) and 100% (methylated: EpiTect Control DNA).
The unbiased estimation of frequencies of lesions (normal, LSIL and HSIL) per HPV/CYTO subset for the entire study population (Table 3) permits calculation of unbiased sensitivity and specificity for detection of histologic HSIL (95% confidence interval in parentheses).
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Furthermore, the "true" and unbiased diagnostic sensitivity estimates often reported (summarised in [ 7]) for MAP-infected animals may be lower than the "effective" sensitivity, if the life expectancy of the individual is shorter than the time where the sensitivity is maximized in the population.
Using an unbiased drug sensitivity testing of primary leukemia cells ex vivo, we recently identified the tyrosine kinase inhibitor axitinib as a selective and highly effective inhibitor for T315I-mutant BCR-ABL1-driven leukemia (Pemovska et al., 2015).
Estimates from the training set applied to an independent validation set (60 stage I to II patients, 98 healthy controls) from two other centers provided unbiased estimates of sensitivity.
A variety of different measures of biological motion processing have been employed in existing studies, ranging from d' as an unbiased measure of sensitivity to biological motion [18], to verbal reports [15], [16].
In fact, under a reasonable general assumption, missing at random (MAR), excluding non-evaluable subjects can provide unbiased estimates of sensitivity (Se) and specificity (Sp).
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