Sentence examples for unbiased readout from inspiring English sources
Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage.
Exon five is in frame with exon four and the terminal exon six; transcripts lacking exon five will therefore not be subject to nonsense-mediated mRNA decay and will provide an unbiased readout of BAX splicing.
To this end, we used the TOPGAL reporter transgenic mouse line, which carries the lacZ gene (encoding β-galactosidase) under the control of three tandem β-catenin-responsive consensus TCF/LEF-binding motifs upstream of a minimal fos promoter, as an unbiased readout system of canonical Wnt activity at different stages post-MI (DasGupta and Fuchs, 1999).
"To facilitate the translation of more personalized therapeutics, we require investigators facile with model systems, informatics, principles of drug action, quantitative signatures of drug exposure, and both mechanism-based and unbiased readouts of drug effects," they write.
We used automated image analysis to quantify BiFC fluorescence readouts within individual cells in an unbiased manner, although other methods are also possible (Morell et al., 2007).
These studies demonstrate the novel and simultaneous application of three key principles, namely unbiased chemical biology, maximally physiologic experimental system and selection of a phenotypic readout.
"We must remain unbiased.
Scientists should be unbiased.
