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Further studies should be conducted to investigate the general applicability of CRP as an unbiased marker of inflammatory activity during treatment of IMPA.
WBC was, as expected, observed not to reflect the inflammatory activity during steroid treatment in a clinical useful manner, whereas, CRP is suggested a valuable unbiased marker of inflammatory activity during steroid treatment in this case.
The high performance achieved using GSAS-based classifeaturesturesuggeststhathathehe GSAS is successfully capturing information about the behavior of the component genes in a given gene set, allowing GSAS to serve as an unbiased marker of metastasis risk.
For these reasons, we tested whether our isotopic model of sugar intake was associated with a second, unbiased marker of total sugar intake recently validated for Yup'ik people: the carbon isotope ratio of RBC alanine (δCALA; 30).
In conclusion, CRP measurements seemed potentially valuable as an unbiased marker of the inflammatory activity during immunosuppressive treatment of type II IMPA in the present case, seemingly providing clinically useful information superior to that of CBC and clinical observations.
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The markers are anonymous and unlikely to target specific expressed genes, therefore they can be considered as neutral, i.e. not under selection and thus are unbiased markers for this investigation of population structure.
We know that tetra-nucleotide markers included in the HGDP-CEPH panel show significantly higher diversity than the unbiased markers developed by Romero et al. (2009).
The cleaned data from the 749 markers [as well a cleaned version of the 16 unbiased markers from Romero et al. (2009)] are available (File S1 and File S2).
In consideration of those drawbacks, a number of studies are focused on developing antigen-independent devices (i.e., micro-infiltration and negative depletion of leukocytes) and searching for unbiased markers which are specifically enriched in CTCs.
Realizing that some of the serum lung cancer biomarkers in our previously reported classifier [ 20] were influenced by bias that was related to blood processing differences, such as contamination by intracellular proteins caused by cell lysis during processing, we set out to identify a new set of unbiased markers.
We therefore hypothesized that the thousands of unbiased genetic markers generated through next-generation sequencing would be ideally suited to determine the origin of synchronous multifocal bladder cancer.
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