Challenges remain, however, as to how to prioritise the large number of discovered connections in an unbiased manner such that the success rate of any following-up investigation can be maximised.
Advanced computational methods have made it possible to study the mechanisms underlying trait connections in an unbiased manner.
To tackle this problem we constructed an unbiased matched-annotation set of connections, and used it in our analysis as the gold standard.
In this review, we highlight how experimental and computational approaches developed recently by our group and others can be effectively used towards elucidating the mitochondrial interactome in an unbiased and systematic manner to uncover network-based connections.
Another advantage of SVAR is the fact that it does not require model pre-specification; therefore, this method is unbiased and makes it possible to infer new connections, not just quantifying the dependence level measured by already known edges.
Pre-launch, just a handful of Circle groups have held meetings, and all of those have a direct connection to Sandberg, meaning they don't offer an unbiased sample.
A trained researcher (EC) facilitated the focus groups with the support of a research assistant, both of whom had no direct connection with NHS Direct that ensured the focus groups were unbiased.
The advantage of WGCNA is that connections between genes can be established in an unbiased manner using disease-relevant expression data.
This unbiased discovery approach has the potential to yield new, previously unsuspected connections between regional brain abnormalities and CKD comorbidities.
Together the identification of these two downregulated modules provides an unbiased starting point based on gene expression for exploring the molecular connections between the TS mutation and the molecular mechanisms of ID [ 9].
In this step, you don't have to let go of the connections, but allow your mind to bring you an unbiased list of examples.
