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We assessed the robustness of the different sample size adjustments for Pareto-like unbalanced trials with misspecification of the ICC.
The reason is that there are many unbalanced trials with the treatment groups being larger than the control groups and simultaneously having the lowest event rates (see Figure 2, left panel).
The higher sensitivity of severely unbalanced trials to the a priori-postulated value of the ICC compared to that of balanced trials emphasized the necessity of a sensitivity analysis on this parameter.
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To check whether our findings emanated from unbalanced trial number between PR and WR trials we repeated the above mentioned analysis for WR trials against those trials with only one object in the test rather than all of PR trials.
Heritability on an entry mean basis was calculated for the phenotyped and genotyped inbred lines according to [ 63] for unbalanced breeding trials.
One factor that could have contaminated our results was unbalanced number of trials between PR (77.8% of all trials) and WR trials (22.2% of all trials).
We aimed to assess whether the clinical equipoise principle is satisfied in unbalanced randomized controlled trials (RCTs) (i.e., with an unequal probability of subjects being allocated to one group than another).
Figure 6 shows the mean value <F loss> of F loss, as a function of the converter efficiency η, for a battery consisting of 10 cells initially unbalanced in each trial of a statistical investigation of 10%%.
This effect makes the oseltamivir and placebo arms of the trial unbalanced for analyses on the subpopulation of participants deemed to be influenza infected, because diagnosis was in part based on an increase in antibody titres over time.
In each run, the number of the sound localization/differentiation trials was unbalanced, with 17 20 localization task trials and 8 11 differentiation control trials.
Two of these three trials were unbalanced, but even choosing the most effective of three interventions in each to lose the imbalance would not affect the result.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com