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Despite limitations (low number of patients, heterogeneous population of septic patients with unbalanced severity between the two groups), the study by Donati and colleagues suggests a positive rheological impact of leukodepleted RBCs in septic patients [ 1].
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For group studies, we prefer crossover designs as these deal effectively with inter-subject variance, but if a more traditional two-group (or more) design is to be used, then block randomisation and/or minimisation should be employed to reduce the risk of the groups becoming unbalanced on key variables such as time since stroke or severity (Altman & Bland, 2005).
While Leone et al. [45] found that de-escalation was inferior to continuation of the initial antibiotic therapy (length of stay as the primary outcome parameter), the study had important limitations (small numbers of patients and unbalanced groups at baseline; patients were younger and had lower disease severity).
The relationship between survival and treatment with oseltamivir or methylprednisolone was investigated by adjusting for factors related to severity in an exact logistic regression analysis, which is appropriate for small amounts or unbalanced binary data (16 ).
Totally unbalanced".
Occasionally, pairings were unbalanced.
Was Cole "unbalanced"?
Unbalanced, I fell.
Lila becomes increasingly unbalanced.
His character was unbalanced.
It was myself, unbalanced.
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CEO of Professional Science Editing for Scientists @ prosciediting.com