Reliable models for plaque complexity, growth or rupture have been unavailable in mice (Bennett, 2002; Cullen et al., 2003).
The generation of a previously unavailable Msh2−/−Msh6−/− mouse has for the first time allowed us to examine the impact of the complete loss of MutSα on lymphomagenesis, CSR and SHM.
(unavailable) Move to mouse to the bottom right hand corner of the screen and click.
PPARγ inhibition was tested by the administration of the PPARγ antagonist GW9662 as PPARγ knock-out mice are embryonically lethal (Barak et al., 1999) and conditional knock-out mice were unavailable.
These models are, however, mainly established in small animals (rats or mice) and mostly unavailable for the assessment of safety and efficacy of extracorporeal support systems [19].
Since serum from such a cross is commercially unavailable, serum derived from C57BL/6 mice was used.
As mentioned in point 2 above, the Gata3fl/fl-Vav-Cre mice are currently unavailable from our collaborators for further analysis due to difficulty in breeding.
When both C5a receptors were unavailable, survival rates in CLP mice were improved and plasma levels of cytokines/chemokines were significantly reduced, suggesting that activation of both C5a receptors occurs in CLP and results in harmful outcomes (Rittirsch et al, 2008).
FKBP12 and FKBP51 levels have been reported in human tissues (Baughman et al., 1997), but data in mouse tissues are largely unavailable.
Involvement of activated platelets is still possible; however, in vivo studies remain difficult as antibodies differentiating human from mouse TSP1 are currently unavailable.
We also observed that SNAP-25 strongly co-expressed with calcyon in human tissues, but its mouse ortholog data was unavailable.
