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Unavailability of macroprolactin levels was another drawback.
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Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin.
In conclusion; there were no significant contributions of macroprolactin to prolactin levels during pregnancy.
In the present study, we aimed to assess the contribution of macroprolactin to high serum prolactin levels and the association of prolactin (PRL) and macroprolactin (macroPRL) levels with thyroid status and thyroid autoimmunity during pregnancy.
Because of the insufficient number of macroprolactin positive patients, correlation analyses were done between the percentages of monoPRL recovery instead of macroprolactinemia.
Conservative estimates suggest that the presence of macroprolactin leads to misdiagnosis in as many as 10%% of all reported instances of biochemical HPRL [ 90].
Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study.
To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy.
The PEG-precipitable PRL, which represents the amount of macroprolactin, is calculated as follows: (total PRL-free PRL /total PRL × 100.
The relationship with anti-PRL autoantibodies and autoimmune disorders has been investigated in some studies due to the structure of macroprolactin [ 18, 19].
In hyperprolactinemic states, the contribution of macroprolactin has been found to be 10 to 25%% of prolactin and macroprolactinemia may be present in about 0.2 3.6 % of the general population [ 9].
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