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Because of the unavailability of effective therapies to block or reverse the progression of androgen-independent prostate cancer, it seems obvious to target growth signaling pathways for which frequently recurring mutations have been identified.
Design and discovery of novel antifungal compounds is the need of time, more than ever before due to the unavailability of effective antifungal therapy to treat resistant fungal infections.
An important caveat to the use of NOACs compared to warfarin has been the unavailability of effective reversal agents.
MPM is an aggressive tumor with an ominous prognosis, due to the unavailability of effective therapeutic regimens.
Although uncommon, this disease constitutes an important health issue due to its severity, its high penetrance, early age at presentation and the unavailability of effective screening tools.
The present data on survival rates after surgery, combined with the unavailability of effective systemic therapies, justify an aggressive surgical approach in patients with hepatic metastases from RCC when a margin-negative resection can be obtained.
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The relatively low content of artemisinin in A. annua and unavailability of cost effective and viable synthetic protocol however, are major obstacles to the commercial production of the drug.
24 Given the unavailability of more effective treatment options, sorafenib has remained the standard of care for the treatment of advanced HCC over the last 5 years.
Although the intervention was well received in most facilities, inadequate allocation of staff time to its implementation, and unavailability of the required wound care supplies, prohibited effective uptake of the intervention across most facilities.
Such approaches are not considered efficient due to the unavailability of real time water quality information, delayed detection of contaminants and not cost effective solution.
Due to the initial unavailability of ARV drugs, many governments did not promote ART as effective and life-saving and warn that other treatments are unproven and potentially dangerous.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com