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These constraints were not dictated by the method we have developed but rather were imposed to allow unambiguous validation against a more established quantification method.
> With criteria defined, a system for appropriate Boolean combination of the criteria was devised such that an unambiguous validation could be ascertained.
We have also moved the model figure to Figure 6 figure supplement 3, as unambiguous validation of this molecular model is not experimentally possible at this time.
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Reproducibility in neuroscience research will improve with enhanced Ab validation, unambiguous identification of Abs used in published experiments, and end user proficiency in Ab-based assays.
This topic has been at times dismissed as metaphysical due to the perceived impossibility to reconcile the individual, first-person perspective of the very meaning of any concept, and the scientific requirements for objective validation, unambiguous communication, systematic reproducibility, and empirical falsifiability.
What will validation validate?
The uploaded datasets, along with essential details, comply with the Genomic Standards Consortium GSCC) and Minimum Information about any (X) Sequence (MIxS) for validation, so that the unambiguous data can be achieved and reused by the scientific community.
We present new randomization tests and cross-validation methods to enable unambiguous statistical inferences for several performance metrics used with the survival-time prediction approach.
In 2004, following five OECD principles for model validation were adopted to validate a QSAR model for its regulatory consideration: a) a defined endpoint; b) an unambiguous algorithm; c) a defined domain of applicability d) appropriate measures for goodness-of-fit, robustness and predictivity and e) mechanistic interpretation, if possible [3].
The principle also supports achievement of the OECD validation principles such as an unambiguous algorithm and a mechanistic interpretation, if possible.
Identification of algorithms and models via web URIs ensure the compliance with the OECD validation principle 2 of "An unambiguous algorithm", as well as repeatability of the results of the model building.
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