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They chose this disease because it is caused by a novel gene not found in healthy individuals, and thus provides a clear and unambiguous target for the therapeutic RNA.
Such studies rely on unambiguous target protein recognition by cognate antibodies.
2) In an unambiguous double-related control condition, both primes addressed the same meaning of an unambiguous target (RR) (e.g., lion stripe tiger).
An aggressive act occurred when one individual threatened an unambiguous target with at least one of the following behaviors: threat grunts, head bob and ground slaps, lunges, chases, and/or bites.
These included 2 unambiguous single-related trials (R1: lion bread tiger; R2: stripe rest tiger), analogue to the ambiguous conditions Rd and Rs, and 2 novel unrelated conditions, in which none of the primes were related to either an ambiguous (UUa; pillow clock ball) or unambiguous target (UU; bread rest tiger).
Similar(55)
We embarked on this unbiased but laborious approach because the malaria field has yet to identify unambiguous targets of protective antibodies.
Because unambiguous targets of protective Abs have yet to be identified in malaria, another approach involves cloning and expressing antibodies from bulk-sorted atypical and classical MBCs to compare their specificity profiles in an unbiased manner using protein microarrays that represent the entire P. falciparum proteome of over 5400 gene products.
Consider an unambiguous mapping of target ranges to phases over the whole transmitted bandwidth requires N-order Costas coded waveform, of duration T, at Nyquist rate.
All matches had to be highest ranking and unambiguous in the target and decoy search.
Unambiguous identification of target metabolites means that chromatographic properties and spectral data of differentiating metabolite are identical to those of authentic standards analysed in the same laboratory.
The high RTs on untaken switch trials is reminiscent of a phenomenon known as saccadic inhibition, in which a the appearance of an irrelevant distracter slows down a planned saccade to an unambiguous, unique, predictable target (J Cogn Neurosci 14 371, 2002; J Neurosci 31:12011, 2011; Vision Res 69 32, 2012).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com