Sentence examples for unambiguous efficacy from inspiring English sources

First, the design should demonstrate unambiguous efficacy related to the disease process so that a sound decision on proceeding, or not, into further clinical development, the so-called "Go/No-Go decision" (G/NG), can be made.

The outcomes of phase III studies conducted with the Aβ monoclonal antibodies bapineuzumab and gantenerumab, as well as another pivotal study carried out with solanezumab, have failed to demonstrate unambiguous efficacy in patients with mild to moderate AD, but they have triggered significant new activity in the study of earlier stages of AD.

In other words, the pharmaceutical industry embraces the disease-oriented approach to medical practice because it provides a simple and unambiguous measure of efficacy for their products.

Although OS is an unambiguous measure of efficacy in clinical trials, its use as a primary end point requires a long duration of follow-up and may prolong the process of identifying novel and potentially beneficial therapy.

Further, reproducibility and validation of genetic association studies in the research area of CM management strongly need standardized and more accurate methods for unambiguous classification of therapy efficacy, till now based on patient self-reports [14, 15].

In conclusion, results of studies on the use of growth factors in the treatment of wounds after laparotomy and vulvectomy as discussed above provide no unambiguous answer with regard to the efficacy and usefulness of these agents.

It was unambiguous in the findings that self-efficacy was an important topic.

To our knowledge, the unambiguous case of a metabolic intermediate building up to toxic levels and leading to efficacy in specific tumor types has not been documented.

Specifically, self-efficacy was predicted to have a positive effect on persistence given unambiguous feedback, but a weak, negative effect given ambiguous feedback.

His unambiguous statement, made in the aftermath of Nelson Mandela's death, has fuelled a bitter debate on the legitimacy and efficacy of sanctions over Israel's treatment of Palestinians.

"Let me be unambiguous.