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The unaffected display of emotion often came into conflict with the code of conduct sanctioned by orthodox teachings.
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Interestingly, Abd-B remained unaffected, displaying a wild type pattern.
Notably, both affected and "unaffected" arms display aberrations with increased time after BCRL onset.
In general, unaffected individuals display fewer than 30 (CTG n CAG n repeats at the DM1 or HD locus.
We find that while both patient and unaffected father display BM defects, the ER-retention of COL4A2 is unique to patient cells.
This is consistent with the unaffected carrier displaying BM defects despite substantial collagen deposition, since studies in heterozygous Col4a1/ Col4a2 knockout mice have establish that reduced collagen levels per se do not result in BM defects (27).
This suggests that unaffected mutation carriers display a more efficient antioxidant defense compared with LHON affected individuals.
However, unaffected mutation carriers displayed the most efficient capacity for reactive oxygen species (ROS) detoxification, which was not hampered by exposure to cigarette derivatives.
The unaffected mutation carrier displayed a trend for progressive impairment in memory, verbal fluency, conceptual shifting and response inhibition, as evidenced by the latest scores either approaching or below the 5th percentile of healthy controls (Fig. 2C).
However, it is not possible to confirm that this feature is associated with NF1 as the twins' older unaffected brother also displayed learning problems during early childhood and responded well to therapy.
While it initially appeared that the Chrome browser for Mac was unaffected and could safely display the symbol, it later crashed Chrome and the software would not reopen without crashing until uninstalled and reinstalled.
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