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The most probable reason for a lower r 2 could be attributed to an unaccounted variable such as time, an important parameter that evaluates the production of Al3+ ions from the electrodes, driving the efficiency of decolorization within the system (Daneshvar et al. 2006a).
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Therefore additional unaccounted variables are of importance when predicting depressive mood in multimorbid patients.
Consequently, the study effect size probably differs not only in the number of participants of each study (sampling error) but also in other unaccounted variables.
Initial inspection of the results from the linear mixed effect model revealed conservative P-value distribution for some factors, implying the existence of unaccounted confounding variables.
Specifically, the effects of unaccounted confounding variables in the context of RCTs (e.g. effect of co-interventions in one arm versus other) have not been systematically evaluated.
Finally, our patients were not part of a randomized study and treatment data were not systematically analyzed; as such, differences in treatments and other unaccounted-for variables could limit our univariate and multivariate models.
With the extensive polymorphism penetration in Toll-like receptors, a poor antibody response to influenza vaccination presents another confounding variable unaccounted for by simply relying on chronologic age.
Lack of adequately powered randomized controlled study (RCT) and variables unaccounted for such fluid balance changes or clustering effect are, however, to be taken into account when interpreting these negative results.
It is also possible that the difference was due to other confounding variables unaccounted for in this study.
While attempts were made to control for these baseline differences in measured variables through regression analysis, potential differences in the above unmeasured variables are unaccounted for – except in as much as they are correlated with measured variables.
One variable that is unaccounted for in these models is branching, a trait that contributes to the final biomass yield, but is not easily measured.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com