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For each Top-event characterised by unacceptable occurrence probability, some design improvements should be made.
Workshop participants agreed that genotoxicity tests in mammalian cells in vitro produce a remarkably high and unacceptable occurrence of irrelevant positive results (e.g. when compared with rodent carcinogenicity).
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Patients with ALK-rearranged tumors who have developed disease progression during alectinib treatment will receive crizotinib monotherapy until disease progression or the occurrence of unacceptable toxicity.
The essential aim of this security check is to determine so-called "exposition scenarios", which facilitates the assessment of the occurrence of unacceptable or dangerous exposure created by the evaluated chemical.
Treatment was continued until disease progression, occurrence of unacceptable toxicity or patient refusal.
The cycles continued until progression of disease, the occurrence of unacceptable toxicities, or patient withdrawal.
Treatment was continued until disease progression or the occurrence of unacceptable toxicity.
Treatment continued until tumour progression, occurrence of unacceptable toxicity or withdrawal of consent.
Patients continued to receive study drugs until disease progression, withdrawal of consent, or occurrence of unacceptable toxicity.
Everolimus was given at a dose of 10 mg daily until progression or occurrence of unacceptable toxicities.
Patients continued to receive chemotherapy in combination with saracatinib until occurrence of unacceptable toxicity or tumour progression.
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CEO of Professional Science Editing for Scientists @ prosciediting.com