However, these methods suffer one or more of the following limitations: the unacceptable low reprogramming efficiency; the labor-intensive removal of reprogramming factors from iPSCs; the requirement for viral packaging or feeder cells.
Although many adjuvants have been proposed over the last few decades, the vast majority have not been successful in being approved for human use, with limitations including unacceptable local or systemic toxicity, manufacturing difficulties, instability, and prohibitive cost [ 18, 19].
Results can be applied for bias errors estimation or correction when fast subsample interpolation is used and application of phase domain interpolation is unacceptable due to processing speed limitations.
Nonspecific distribution, which results in insufficient drug accumulation in the tumor, off-target attack of normal cells, and unacceptable toxicity are the major limitations of current chemotherapeutic agents.
Given the importance of psychiatric conditions in primary care practice with a prevalence of more than 20% [ 66], this limitation is simply unacceptable.
A tenured scientist at Virginia Commonwealth, who would not be interviewed for attribution because he said he feared retribution against his junior colleagues, called the contract's restrictions, especially the limitations on publication, "completely unacceptable in the research world".
Esophageal and electrolaryngeal speech do also have some inherent limitations that may have been unacceptable to most Jordanian laryngectomees, just as they have been for some larygnectomees in other parts of the world.
2, 21 The microneutralization test that we used was developed at the WRAIR Pilot Bioproduction Facility to overcome many of the PRNT's limitations, such as its low throughput, unacceptable labor-intensive nature, and high degree of interassay variability.
Bumb also points out the technical limitations involving signal loss, high background interference and unacceptable toxicity that have sidelined research endeavors.
