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All of these coatings can ensure the water solubility of Q-dots, but they are unable to enhance biocompatibility.
We made the surprising observation that CD4mc are unable to enhance recognition of HIV-1-infected cells by this family of antibodies in the absence of antibodies such as 17b, which binds a highly conserved CD4-induced epitope overlapping the co-receptor binding site (CoRBS).
Prolonging the PP duration to 50 ms was unable to enhance the efficacy of BmK IT2 (data not shown).
In this study, OCA and TCA were unable to enhance hrpA or hrpN expression of the ΔrsmB, ΔgacS, and ΔgacA mutants of Ech3937 (Table 4).
STC1 was unable to enhance the calcium wave following incubation with U73122 indicating that STC1 was dependent on canonical PLC activation (Figure 5D).
Additionally, overexpression of vimentin induced by stable transfection of expression constructs in tumoral cells was unable to enhance invasiveness in poorly invasive prostatic tumor [25] or was shown, on the contrary, to decrease hepatocarcinoma proliferation [26].
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Nonetheless, the combination of IL-2+ IL-12+ IL-18 was unable to significantly enhance expression of CD107a or IL-2 (Fig. 3A) and only modestly enhanced granzyme B release (Supp. Fig. S2A).
Collectively, these observations suggest that FGF signalling was unable to induce, enhance or pattern mesoderm formation from EPL cells in culture.
Further analysis revealed that the corresponding constitutively expressed (noninducible) TALE-TFs were also unable to significantly enhance gene expression, suggesting an inherent limitation within these TALEs or their target sites (Supporting Information Figure S3).
While RAPA PLGA NPs alone were able to decrease the number of blood vessels through antiangiogenic activity and normalize blood vessels, they were unable to significantly enhance penetration of PLGA NPs into the tumor through microenvironment modulation as illustrated in Figure 10.
However, a number of studies using biopsies in Ussing chambers have also been unable to demonstrate enhanced glucose absorption in cystic fibrosis [ 29- 31].
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